Using Single-cells to Understand Treatment Resistance in Childhood Cancer

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A bee colony requires the queen to survive but identifying the queen can be challenging without inspection of individual bees. Similarly, we seek to find cancer cells that act like a queen bee, cells that can mediate relapse and treatment resistance. To do this, we use single-cell, high dimensional approaches to identify cancer cells associated with treatment resistance.We learn from studies in primary patient samples to guide further mechanistic investigations.

Our goal is to improve risk stratification and outcomes for patients by finding and targeting the most clinically relevant cells, those that cause relapse, the queen bees.

Research Areas

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Developmental Biology of Acute Leukemia in Children

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Drug Resistance and Response: Chemotherapy, Immunotherapy and More

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The Role of Metabolism in Acute Lymphoblastic Leukemia

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Single-cell Lineage Architecture and Immune Environments of Neuroblastoma

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Outcome Prediction from Single-cell Studies

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The Davis lab is always looking for bright, kind, and creative people who are interested in making relapse in childhood cancer a thing of the past.

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